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KMID : 1142020210560020065
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Blood Research
2021 Volume.56 No. 2 p.65 ~ p.71
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Clinical impact of cell-free serum Epstein?Barr virus status in patients with newly diagnosed malignant lymphoma
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Baek Dong-Won
Lee Jung-Min
Kim Ju-Hyung
Cho Hee-Jeong
Sohn Sang-Kyun
Ham Ji-Yeon
Chang Soon-Hee
Moon Joon-Ho
Yang Deok-Hwan
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Abstract
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Background: We analyzed cell-free serum Epstein?Barr virus (EBV) DNA to identify its prognostic role in patients with newly diagnosed lymphoma.
Methods: We retrospectively reviewed patients diagnosed with lymphoma between January 2014 and July 2020. Patients were enrolled according to the following criteria: i) pathologically confirmed lymphomas according to the World Health Organization criteria, ii) age over 18 years, iii) serum EBV DNA measurement using polymerase chain reaction prior to first-line therapy, and iv) receipt of curative standard chemotherapy. In total, 263 patients met these criteria and were included in this study.
Results: Serum EBV DNA was detected in 79 patients (30.0%). Patients with positive serum EBV tended to be older (P =0.090), and the proportion of T-cell lineage lymphomas was higher than that of B-cell lymphomas (P =0.003). EBV positivity was significantly associated with more advanced disease based on the Ann Arbor staging system (P =0.008) and the International Prognostic Index (P =0.009). EBV positivity was also associated with higher disease relapse (P =0.038) and death rates (P =0.005). EBV-positive lymphomas further showed inferior long-term survival outcomes in terms of progression-free survival (PFS) (P=0.053) and overall survival (OS) (P=0.014). In the subgroup analyses, serum EBV positivity was a significant prognostic factor for patients with B-cell lineage lymphomas in terms of PFS (P =0.003) and OS (P=0.033).
Conclusion: We demonstrated that cell-free serum EBV DNA status at the time of diagnosis has potential as a prognostic biomarker for patients with newly diagnosed malignant lymphomas.
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KEYWORD
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Epstein?Barr virus, Lymphoma, Prognosis, Biomarker
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